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Vayne & Nami vs Ezreal & Thresh

Bot Lane Matchup

Vayne vs Ezreal (with Nami & Thresh) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, you lose the 2v2 — Thresh's Q into E combo at level 2 can burst you before Nami's W heals you back, and your short auto-attack range means you take poke without reliable retaliation against Ezreal's Q.
Post-6, your R fundamentally changes the matchup; the stealth makes Thresh's Q much harder to land reliably, and your Silver Bolts shred both enemies in a prolonged fight that you can now survive with Nami's healing.

Your best pattern is to play passive and farm until you have enough Silver Bolts stacks to threaten burst, then use E to knock Thresh or Ezreal into a wall when they overextend for a hook.
Let Nami's W sustain you through poke phases and look for the E wall-pin on Thresh specifically, as removing his engage threat opens the lane.

Play for a slow freeze near your tower in the early game — this denies Thresh the space to hook you safely and forces Ezreal to walk up into Thresh's range to poke.
Once you hit level 6 and have your first item component, you can start pushing out and looking for skirmishes.

Do not E into Thresh when he has Q available — you will knock him toward you and he will immediately Q you back, creating a double-CC chain that Ezreal can follow up on for a kill.
Save E strictly for wall-pins or escaping Thresh's hook follow-up.

Created on 06/30/2026

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