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Ezreal & Thresh vs Vayne & Nami

Bot Lane Matchup

Ezreal vs Vayne (with Thresh & Nami) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, you do not win the 2v2 cleanly — Vayne outranges you at close range with E and Nami's W sustain negates your poke over time, but your Q poke is safer than Vayne's auto-attack pattern if you respect positioning.
Post-6, your R is a global reset tool but does not win the lane fight; Vayne's R stealth makes her extremely hard to burst, and Nami's R can interrupt your engage entirely.

Your best pattern is to Q poke Vayne repeatedly from max range to force Nami to spend W charges, then when Thresh lands a hook, follow with W auto-attack reset into Q for a quick burst trade and disengage immediately.
Do not commit to extended fights — your damage falls off in sustained exchanges against Vayne's on-hit scaling.

Push the wave with Q to force Vayne under tower where her short-range E is less effective, denying her the space to freely stack Silver Bolts on you.
Avoid freezing the wave near your tower, as Vayne excels at farming safely under pressure and Nami can sustain her through any poke you throw.

Do not use E aggressively into Vayne — she will E you into the wall the moment you close distance, and Nami's R can cancel your escape blink if timed correctly.
Keep E as a defensive tool to dodge Nami's Q bubble or to reposition away from Vayne's R all-in.

Created on 06/30/2026

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