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Who Wins
- Pre-6, your E+auto harass is strong but Nautilus's Q threat forces you to play cautiously — if Nautilus hooks Miss Fortune instead of you, you can freely E+R drain her, but if he hooks you, Miss Fortune's R into your CC is lethal.
- Post-6, your R sustain makes extended 2v2 fights heavily favor your side, but only if Ezreal has his E available to escape Nautilus's initial engage and reset the fight into a sustained brawl.
Synergy & Trading
- Your best pattern is to E onto Miss Fortune when Nautilus has Ezreal occupied, forcing her to either stand still and take drain damage or move away from her R channel.
- If Nautilus lands Q on Ezreal, immediately E onto Ezreal as well to stack CC duration and activate R for maximum drain value during the lockdown window.
Wave Control/Roaming
- You should roam to mid at level 6 when the wave is pushed into the enemy tower, as your R sustain means you can return to lane at full health and your E+R combo provides strong kill pressure on most mid laners.
- Avoid roaming pre-6 since your kill pressure without R is insufficient to justify leaving Ezreal alone in lane.
Mistakes to Avoid
- Do not activate R immediately at the start of a fight — wait until you have landed E and confirmed that at least one enemy is CC'd by Nautilus, otherwise you waste R duration on enemies who will simply walk out of range.
- Premature R activation against a mobile Ezreal is the primary reason this duo loses fights they should win.
Created on 08/15/2026
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