Seraphine & Nautilus vs Vayne & Senna
Bot Lane Matchup
You
VS
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Who Wins
- You lose pre-6 due to Vayne's superior all-in potential with Nautilus engage and lack early damage to punish her short range.
- Post-6 you win teamfights but still struggle in pure 2v2s due to Vayne's mobility and damage output.
Synergy & Trading
- Poke with Q when Vayne steps up for CS, then follow with auto-attack for passive proc.
- Use W to sustain through Senna poke and save E for when Nautilus engages or Vayne tries to all-in.
Wave Control/Roaming
- Push waves early to establish priority and enable Nautilus roams, but avoid overextending without vision.
- Focus on building item advantages through safe farming rather than forcing trades.
Mistakes to Avoid
- Don't use E aggressively for poke as it's your only escape tool against Nautilus Q engage.
- Avoid standing in minion waves where Senna can Q through creeps to hit you.
Created on 12/16/2025
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