Senna & Vayne vs Seraphine & Nautilus
Bot Lane Matchup
You
VS
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Who Wins
- You lose pre-6 due to Nautilus's all-in potential overwhelming your limited early mobility and damage.
- Post-6 you have better teamfight utility but still struggle in direct 2v2 engagements.
Synergy & Trading
- Poke with Q through minions to hit both enemies while healing Vayne, then follow with auto-attacks for soul collection.
- Save W for when Nautilus engages or to set up Vayne's condemn angles.
Wave Control/Roaming
- Roam mid-game when you have items and your utility becomes more valuable than laning presence.
- Look for roam timings after shoving waves or when Vayne can safely farm alone.
Mistakes to Avoid
- Don't waste W defensively too early as it's your main disengage tool against Nautilus engage.
- Avoid standing too close to Vayne where Seraphine can hit both of you with E-R combo.
Created on 12/16/2025
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