Nautilus & Seraphine vs Vayne & Senna
Bot Lane Matchup
You
VS
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Who Wins
- You win pre-6 if you can land Q on either enemy, as your all-in with Seraphine follow-up outdamages their response.
- Post-6 becomes more difficult as Vayne's R makes her harder to catch and Senna provides more peel.
Synergy & Trading
- Look for Q angles when enemies are farming or when Senna steps forward to Q poke.
- Follow up with W-E combo while Seraphine adds Q-E for maximum burst damage.
Wave Control/Roaming
- Roam frequently after shoving waves, especially to mid lane or jungle skirmishes where your CC is valuable.
- Time roams when Vayne is farming under tower and can't follow quickly.
Mistakes to Avoid
- Don't waste Q on minions or use it when enemies have escape tools available.
- Avoid engaging when Senna has her root available and Vayne can kite backwards with Q.
Created on 12/16/2025
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