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Pyke & Twitch vs Caitlyn & Nami

Bot Lane Matchup

Pyke vs Caitlyn (with Twitch & Nami) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, you do not win the 2v2 cleanly because Caitlyn's range lets her poke both you and Twitch before you can close distance, and Nami's Q bubble stops your E hook attempts.
Post-6, your R execute combined with Twitch's R spray damage makes you heavily favored in all-ins, but only if you can land your E on Caitlyn rather than Nami.

Your best pattern is to use W to regenerate health in brush while Twitch stacks poison from stealth, then commit your E hook onto Caitlyn when she steps forward to poke, chaining into Twitch's full combo.
Do not hook Nami as your primary target because she is the less threatening kill and Caitlyn will freely damage Twitch during your cooldowns.

You should roam aggressively once Twitch hits level 6 and the wave is pushed, because your R execute threat on other lanes combined with Twitch's stealth means the bot lane is relatively safe and your roam pressure is among the highest in the game.
Optimal roam timing is after a successful poke trade where Caitlyn is forced to back, leaving Twitch to safely freeze.

Do not use your E hook from a predictable angle because Caitlyn's E trap placement in common hook paths will root you mid-dash and Nami's Q bubble will follow immediately, turning your engage into a death.
Burning your E on a Nami who is positioned in front of Caitlyn is a wasted cooldown that leaves Twitch completely exposed.

Created on 07/28/2026

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