Nautilus & Vayne vs Ezreal & Nami
Bot Lane MatchupNautilus vs Ezreal (with Vayne & Nami) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
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VS
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Who Wins
- You lose pre-6 2v2s because Nami can disengage your hooks with Q and sustain through your damage with W healing.
- Post-6 you win if you land R on either target since your lockdown chain is longer than their disengage tools.
Synergy & Trading
- Look for Q hooks when Ezreal steps up to last hit or when Nami moves forward to W heal, then follow with E slow and passive root.
- Time your engage when Nami's Q is on cooldown since that's their primary disengage tool.
Wave Control/Roaming
- Roam after shoving waves when Vayne can farm safely, targeting mid lane around levels 4-6 when your Q-E-passive combo can secure kills.
- Don't roam if Vayne is behind or the wave is in a bad spot since she'll get dove.
Mistakes to Avoid
- Don't waste Q on minions or miss hooks when Ezreal has E available since you won't get another engage window for 18 seconds.
- Avoid hooking when Nami is positioned to immediately Q bubble your follow-up engage.
Created on 02/24/2026
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