Nami & Ezreal vs Vayne & Nautilus
Bot Lane MatchupNami vs Vayne (with Ezreal & Nautilus) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
You
VS
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Who Wins
- You win pre-6 2v2s through W sustain and Q disengage against their short-range all-in attempts, plus E empowers Ezreal's poke.
- Post-6 you lose if Nautilus lands R since your disengage tools can't stop their full combo lockdown.
Synergy & Trading
- Use W to sustain Ezreal through Vayne's short trades and E to empower his Q poke for better trading.
- Save Q for when Nautilus hooks forward so you can bubble him mid-engage and turn the fight.
Wave Control/Roaming
- Don't roam early since Ezreal needs your sustain and disengage against Nautilus engage potential.
- Consider roaming post-6 only when you have deep wards and Ezreal can safely farm with E escape available.
Mistakes to Avoid
- Don't use Q aggressively for poke since you need it to disengage Nautilus hooks and all-ins.
- Avoid positioning too far forward when using W since Nautilus can flash-Q you if you're out of position for healing.
Created on 02/24/2026
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