Twitch & Pyke vs Caitlyn & Nautilus

Twitch
You
Pyke
VS

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Who Wins

  • You lose most pre-6 trades due to Caitlyn's range and Nautilus's engage threat, but post-6 your stealth+R gives you strong all-in potential if you can avoid their initial burst.
  • Focus on farming safely and looking for stealth flanks after 6.

Synergy & Trading

  • Use Q stealth to reposition for favorable trades, then auto+E when Caitlyn steps forward to harass.
  • Let Pyke initiate with E or Q, then follow up with your damage while they're locked down.

Wave Control/Roaming

  • Farm under tower and let waves push to you, using Q to escape ganks and avoid Nautilus hooks.
  • Only look to trade when Pyke lands crowd control or when you can stealth flank from unwarded positions.

Mistakes to Avoid

  • Don't try to trade auto-for-auto with Caitlyn in early levels, as her range and headshot passive will win every extended trade.
  • Never use Q aggressively without knowing where their jungler is, as you have no escape once it's down.
Created on 12/08/2025
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