Nautilus & Caitlyn vs Twitch & Pyke

Nautilus
You
Caitlyn
VS
Twitch
Pyke

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Who Wins

  • You dominate pre-6 with superior all-in potential through Q+passive+E combo, but post-6 becomes skill-dependent as Pyke's R resets can turn fights around.
  • Your engage is more reliable but Pyke's mobility makes him harder to lock down.
Confused by a term? Check the Glossary

Synergy & Trading

  • Look for Q hooks when Twitch steps up for CS, then immediately follow with passive auto+E to lock him down for Caitlyn's damage.
  • Use W shield to absorb Pyke's poke and maintain pressure in lane.

Wave Control/Roaming

  • Roam mid or jungle after pushing waves, especially levels 3-5 when your Q+passive combo is strongest and before Pyke gets his ultimate.
  • Time roams when Twitch is forced to farm under tower and can't follow quickly.

Mistakes to Avoid

  • Don't waste Q on minions when enemies are in range, as it's your primary engage tool with a long cooldown.
  • Avoid fighting in river or jungle without vision, as Pyke's E+R combo in tight spaces is much more dangerous than in lane.
Created on 12/08/2025
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