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Nautilus & Ezreal vs Seraphine & Heimerdinger

Bot Lane Matchup

Nautilus vs Seraphine (with Ezreal & Heimerdinger) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, you win this lane — your level 2 Q hook into E root is one of the most punishing all-ins in the game, and Seraphine and Heimerdinger both have low mobility to escape it; however, Heimerdinger's E can stun you mid-engage if you walk into it carelessly.
Post-6, Seraphine R is a serious threat to your engage because it can charm you mid-hook animation or chain CC your entire team, so you must look to hook before she can react.

Your best pattern is to walk up as if to hook, bait Seraphine into using her E shield early, then back off and re-engage 4–5 seconds later when her E is on cooldown — once her E is gone, your full Q-W-E chain into Ezreal follow-up is nearly a guaranteed kill.

You should roam — yes.
After a successful level 2 or level 3 all-in that burns Seraphine and Heimerdinger's summoners or kills one of them, back, buy, and look to roam mid at level 6 because your R is one of the strongest roam tools in the game and Seraphine's wave push will have shoved the wave, giving you a roam window.

Do not hook into Heimerdinger's turret cluster without Ezreal being in position to follow up — you will take heavy turret damage, Seraphine will E-shield herself and Heimerdinger, and you will come out of the trade heavily losing with no kill to show for it.

Created on 06/28/2026

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