Who Wins
- Pre-6: You lose most trades due to shorter range and vulnerability to Lux Q, but can win if Seraphine lands good poke first.
- Post-6: You scale better but still lose all-ins until 2-3 items due to Vayne's mobility and burst potential.
Synergy & Trading
- Stay behind Seraphine and follow up on her Q slow with your Q-W combo for extended trades.
- Focus on farming safely and only trade when Seraphine creates opportunities with her CC.
Wave Control/Roaming
- Farm passively and let Seraphine control the wave early, then look to freeze near your tower once you have items.
- Avoid pushing without vision since you're extremely vulnerable to ganks and Vayne engages.
Mistakes to Avoid
- Don't try to match Vayne's aggression or positioning - you need to play for scaling and teamfights.
- Never walk up without Seraphine's protection abilities available, as Vayne can easily run you down.
Created on 04/02/2026
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