Thresh & Varus vs Miss Fortune & Zyra

Thresh
You
Varus
VS
Miss Fortune
Zyra

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Who Wins

  • Pre-6 you lose sustained trades but can win short burst trades if you land Q on either enemy and follow up immediately.
  • Post-6 your team wins all-ins if you can land Q before Miss Fortune channels R, as your CC chain with Varus R becomes overwhelming.
Confused by a term? Check the Glossary

Synergy & Trading

  • Look for Q angles when enemies step up to trade or when Miss Fortune uses Q, then immediately follow with E-auto-ignite for maximum burst.
  • Use W to reposition Varus for better angles or to escape Zyra's follow-up after trades.

Wave Control/Roaming

  • Roam after successful recalls when the wave is pushing away from you, typically around levels 4-6.
  • Look for mid lane ganks when your jungler is nearby, as your Q-E combo sets up easy kills.

Mistakes to Avoid

  • Don't waste Q on Zyra plants or when enemies have easy escape routes through minions.
  • Never engage without vision of the enemy jungler, as Miss Fortune and Zyra have excellent gank setup with their AOE damage and CC.
Created on 05/18/2026
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