Who Wins
- Vayne + Lulu wins level 2 all-ins due to Vayne's Q mobility and Lulu's W polymorph disrupting your damage output.
- At level 6, they still have the advantage since Vayne's R stealth negates your R execute potential and Lulu's R provides massive survivability.
Synergy & Trading
- Focus on Q poke from maximum range while Milio uses his E to shield incoming Vayne Q-AA trades.
- Your optimal trading window is when Vayne uses Q aggressively - immediately W to slow her retreat and follow with Q-AA while Milio provides E shield and healing.
Wave Control/Roaming
- Push early waves to build Q stacks safely, then transition to freezing near your tower once Vayne hits her power spikes.
- You need to prioritize stack accumulation over CS leads since your scaling potential outweighs short-term gold advantages.
Mistakes to Avoid
- Never use R aggressively without vision of jungle ganks since Vayne's R stealth makes it nearly impossible to confirm kills.
- Avoid extended trades when Lulu's W is available as the polymorph will completely negate your damage window and leave you vulnerable to Vayne's follow-up.
Created on 11/27/2025
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