Nautilus & Senna vs Samira & Thresh

Nautilus
You
Senna
VS
Samira
Thresh

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Who Wins

  • You win pre-6 2v2s through your tankiness, crowd control chain, and Senna's range advantage creating favorable trades.
  • Post-6 you maintain advantage but must be careful of Thresh R disrupting your engage combos.
Confused by a term? Check the Glossary

Synergy & Trading

  • Engage with Q when Thresh abilities are on cooldown, then use W and E to lock down Samira while Senna follows up with damage.
  • Your R can interrupt Samira's R channel or force her to use W defensively.

Wave Control/Roaming

  • Roam after pushing waves level 4-6 when you have boots, targeting mid lane or jungle skirmishes.
  • Your crowd control chain is extremely valuable for securing kills in other lanes during this window.

Mistakes to Avoid

  • Don't waste Q on Thresh unless it's a guaranteed kill - focus your crowd control on Samira who is the primary damage threat.
  • Missing Q gives them a window to engage on Senna while your key ability is on cooldown.
Created on 06/08/2026
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