Maokai & Kai'Sa vs Vayne & Nautilus

Maokai
You
Kai'Sa
VS
Vayne
Nautilus

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Who Wins

  • You win pre-6 through E bush control, superior poke, and range advantage with Kai'Sa's Q harassment.
  • Post-6 becomes risky as Nautilus R + Q enables Vayne's R stealth and E wall condemns for quick kills.
Confused by a term? Check the Glossary

Synergy & Trading

  • Use E in bushes to zone and slow, then W engage when Nautilus wastes Q hook or is low on mana.
  • Let Kai'Sa stack plasma with Q + W before your W engage to maximize damage output during your CC duration.

Wave Control/Roaming

  • Roam after level 6 when your W + R combo becomes powerful for ganks, especially when Kai'Sa can safely farm or has item advantages.
  • Time roams when Nautilus shows elsewhere or after forcing them to recall.

Mistakes to Avoid

  • Don't W engage when Vayne has R available near walls as she can stealth and reposition for E condemn during your animation.
  • Avoid extended trades in open areas where your E saplings provide less zone control and Vayne can kite freely.
Created on 02/12/2026
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