Who Wins
- You lose pre-6 due to Lux's superior range and poke damage, with your W being your only reliable trading tool.
- Post-6 the matchup improves significantly as your R can counter Lux burst while enabling Vayne's assassination potential on either target.
Synergy & Trading
- Use W on Caitlyn when she steps up to auto Vayne, then shield Vayne to help her trade back effectively.
- Look for E-Q poke combos when enemies are grouped or when Caitlyn uses E aggressively, as this creates windows for favorable trades.
Wave Control/Roaming
- Avoid roaming early as Vayne needs constant protection and peel against this lane's poke pressure.
- Only roam post-6 when Vayne has R available and can potentially 1v2, or when enemies recall and you can make plays elsewhere safely.
Mistakes to Avoid
- Don't use W randomly for poke as the cooldown is long and Vayne needs it for protection against all-ins.
- Never position where Lux can Q both you and Vayne simultaneously, as this removes all your peel potential and guarantees a lost fight.
Created on 12/04/2025
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