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Galio & Cassiopeia vs Caitlyn & Seraphine

Bot Lane Matchup

Galio vs Caitlyn (with Cassiopeia & Seraphine) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, this lane is roughly even to slightly losing because Seraphine's E root and Caitlyn's traps punish your engage attempts hard, and your W shield helps but doesn't fully negate their sustained poke.
Post-6, your R is the primary win condition for this lane, but Seraphine's R can counter-engage and Caitlyn's traps will be placed to punish your landing zone, so you must coordinate carefully.

Your best trading pattern is to use W to absorb Seraphine's poke, then look for an E taunt onto Caitlyn specifically, as she is the squishier target without a reliable escape; Cassiopeia can then stack E damage on the taunted Caitlyn.
Avoid taunting Seraphine first, as Caitlyn will freely headshot Cassiopeia during the taunt duration.

You should roam when the wave is pushed into the enemy tower and Cassiopeia has enough wave clear to maintain pressure; your R is one of the strongest roam tools in the game and mid-lane assassins or divers will love the setup.
Avoid roaming pre-6 because Cassiopeia is not self-sufficient enough to survive a 1v2 dive or hard poke without your presence.

Do not use your R as a pure escape tool or waste it on a single target when both enemies are grouped; the value of your R in this matchup is catching both Caitlyn and Seraphine in the stun to let Cassiopeia R them simultaneously.
Burning your R defensively leaves Cassiopeia with no engage path and concedes the lane tempo entirely.

Created on 09/21/2026

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