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Cassiopeia & Galio vs Caitlyn & Seraphine
Bot Lane MatchupCassiopeia vs Caitlyn (with Galio & Seraphine) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
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Who Wins
- Pre-6, you lose the 2v2 because Caitlyn's range advantage and Seraphine's poke and slow make it nearly impossible to land your Q to enable E spam; you are not a level 1-3 lane bully here.
- Post-6, your R is a game-changer if you can get in range, but Galio's R engage is required to close the gap since Caitlyn will kite you indefinitely without it.
Synergy & Trading
- Your best trading pattern is to wait for Galio to land his E taunt or R engage, then immediately Q the poisoned target and spam E to stack damage before they can disengage; never try to initiate trades yourself into Caitlyn's range without setup.
- Trading without Galio's CC is a losing proposition because Seraphine's W shield and heals will out-sustain your poke at that range.
Wave Control/Roaming
- You want to push the wave hard with E spam to deny Caitlyn her preferred poke range under a slow-push setup; a fast-pushed wave forces them under tower where Caitlyn's traps lose value and Seraphine's poke is less effective.
- Avoid letting the wave freeze near their tower, as that gives Caitlyn a safe farm environment and denies you the ability to walk up.
Mistakes to Avoid
- Do not try to walk up and auto-attack or Q fish in isolation against Caitlyn's range; her auto-attack range at 650 means she will out-trade you in extended poke wars before your Q lands.
- Overextending without Galio's peel or engage setup will result in you burning Flash or dying to a Seraphine R into Caitlyn headshot combo.
Created on 09/21/2026
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