Alistar & Vayne vs Smolder & Karma

Alistar
You
Vayne
VS
Smolder
Karma

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Who Wins

  • You win level 2 fights decisively with W-Q combo into Vayne follow-up damage.
  • At level 6, your engage becomes even stronger with ultimate tankiness while they gain minimal combat power.
Confused by a term? Check the Glossary

Synergy & Trading

  • Look for W-Q combos when enemies are positioned poorly, then tank damage while Vayne follows up.
  • Use E for additional crowd control and healing during extended trades.

Wave Control/Roaming

  • You shouldn't roam much early since this lane has high kill pressure with proper engages.
  • Only roam after securing kills or when Vayne can safely farm alone with level advantage.

Mistakes to Avoid

  • Don't engage without minion advantage or when Karma has Mantra E ready for disengage.
  • Missing your W-Q combo leaves Vayne vulnerable and wastes your main engage window.
Created on 11/14/2025
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