Who Wins
- You lose pre-6 as your Q poke can't match their range advantage and burst potential, while your healing can't sustain through consistent Karma+Caitlyn poke.
- Post-6 you gain more impact through E movement speed enabling Twitch flanks, but still lose direct 2v2 confrontations without perfect execution.
Synergy & Trading
- Use Q to poke when enemies are locked in animation (Caitlyn Q or Karma Q), then immediately E Twitch for movement speed if they try to retaliate.
- When Twitch uses Q stealth, detach briefly to bait enemy abilities, then reattach when he reveals for maximum surprise damage.
Wave Control/Roaming
- Don't roam early as Twitch needs your sustain and protection to survive the lane phase against their superior range and poke.
- Stay attached and focus on keeping Twitch healthy until level 6, when you can enable his flanking potential with E movement speed.
Mistakes to Avoid
- Don't detach unnecessarily to land Q poke - you're too vulnerable to Karma W root and Caitlyn follow-up damage.
- Avoid using E for movement speed casually, save it for escaping their all-in attempts or enabling Twitch's stealth engages when you have kill potential.
Created on 01/03/2026
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