Who Wins
- Pre-6 you win most trades with Q poke and Zilean's bomb combos outranging their abilities significantly.
- Post-6 you dominate with R execute potential on Vayne, even through Janna's E shield.
Synergy & Trading
- Use Q to poke Vayne whenever she steps up for CS, and coordinate with Zilean's Q-W-Q when enemies are positioned aggressively.
- Save E for when Vayne tries to engage or when setting up kills with Zilean.
Wave Control/Roaming
- Push waves aggressively to stack Q on minions while pressuring enemies under tower.
- This matchup favors constant pressure since your range advantage is most effective when enemies can't farm freely.
Mistakes to Avoid
- Don't waste E cage for minor trades as it's your primary self-peel against Vayne's potential all-ins.
- Missing E when Vayne has R available can result in her running you down despite your range advantage.
Created on 05/31/2026
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