Vayne & Thresh vs Caitlyn & Mel

Vayne
You
Thresh
VS
Caitlyn
Mel

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Who Wins

  • Pre-6: You lose to their superior range and poke damage, focus on farming safely.
  • Post-6: Still difficult due to Mel's W reflecting your burst damage back, but you can win if you dodge her E root.
Confused by a term? Check the Glossary

Synergy & Trading

  • Wait for Thresh to land hook, then tumble forward for Silver Bolts proc while they're locked down.
  • Only trade when Mel's W is down and you can avoid her E root with proper positioning.

Wave Control/Roaming

  • Let the wave push to you and farm under tower to avoid their poke damage.
  • Ask for jungle help when they overextend, as they have limited escape tools once committed.

Mistakes to Avoid

  • Don't try to trade when Mel has W available - she'll reflect your damage back and win the exchange.
  • Avoid getting caught by her E root as it sets up easy follow-up damage from both enemies.
Created on 02/12/2026
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