Vayne & Nami vs Miss Fortune & Nautilus

Vayne
You
Nami
VS
Miss Fortune
Nautilus

Tap any portrait to switch perspective

Who Wins

  • Miss Fortune + Nautilus wins pre-6 through superior range advantage and Nautilus hook threat forcing defensive positioning.
  • Post-6 their ultimate combination remains stronger, but you gain outplay potential with R stealth if you can avoid initial CC chain.
Confused by a term? Check the Glossary

Synergy & Trading

  • Use Q to dodge Nautilus Q, then immediately auto-E-auto for Silver Bolts proc while Nami provides E empowerment.
  • Avoid extended trades without Nami W sustain available, as Miss Fortune's Q poke will gradually wear you down.

Wave Control/Roaming

  • Freeze near your tower to force enemies to overextend for CS, making Nautilus hooks more risky.
  • Only push when you have clear recall timing or roam opportunity, as your short range makes you vulnerable when extended.

Mistakes to Avoid

  • Don't use E aggressively for trades early game - save it primarily for self-peel against Nautilus engages.
  • Using E offensively leaves you completely vulnerable to their superior all-in potential.
Created on 02/21/2026
🛠️ Something wrong?