Senna & Seraphine vs Miss Fortune & Milio

Senna
You
Seraphine
VS
Miss Fortune
Milio

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Who Wins

  • You win pre-6 2v2s through superior range advantage and Seraphine's poke support, as Milio lacks meaningful trading tools.
  • Post-6, you maintain advantage as your scaling damage and Seraphine's R provide better all-in potential than their defensive setup.
Confused by a term? Check the Glossary

Synergy & Trading

  • Use Q to poke Miss Fortune while collecting souls, then follow Seraphine's Q or E with your W root for extended trades.
  • Position aggressively to deny Miss Fortune's Q bounces while maintaining soul collection.

Wave Control/Roaming

  • You should roam after pushing waves to collect souls in river or enemy jungle, especially when Seraphine has wave clear advantage.
  • Time roams around your soul collection patterns and when Miss Fortune is forced to farm under tower.

Mistakes to Avoid

  • Don't get caught by Miss Fortune's Q bounces by standing directly behind low-health minions.
  • Avoid face-checking bushes without Seraphine's E shield as Milio's Q can set up dangerous all-ins if you're caught alone.
Created on 06/14/2026
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