Pyke & Vayne vs Jhin & Milio

Pyke
You
Vayne
VS

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Who Wins

  • You lose pre-6 poke wars due to Jhin's range and Milio's sustain, but win post-6 all-ins with R execute potential.
  • Focus on surviving early rather than forcing trades you can't win.

Synergy & Trading

  • Land Q hooks to enable Vayne's follow-up damage, then use E for guaranteed stuns after she commits.
  • Your R execute timing is crucial - wait for Milio's W cleanse to be used before engaging.

Wave Control/Roaming

  • Roam frequently after level 6 when your R becomes available, especially to mid lane for picks.
  • Time roams when the wave is pushing toward your tower and Vayne can farm safely.

Mistakes to Avoid

  • Don't hook without E follow-up available, as Milio's R will knock you away from your target.
  • Never R too early in fights - wait until enemies are low enough that Milio's healing can't save them.
Created on 04/17/2026
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