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Neeko & Zeri vs Jinx & Seraphine

Bot Lane Matchup

Neeko vs Jinx (with Zeri & Seraphine) BOT matchup tips: who wins, how to trade, wave control and common mistakes.

You

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Who Wins

Pre-6, your level 2 E root spike is significant — if you land E on Jinx at level 2 before Seraphine has her E, you can force a flash or get a kill with Zeri following up.
Post-6, your R is the primary win condition for the 2v2, but Seraphine's R has longer range and can interrupt your R channel if she lands it first, so you do not automatically win post-6 teamfights.

Your best pattern is to Q poke Jinx repeatedly to stack your passive damage, then when she's low enough, use E root to lock her in place for Zeri to burst; your W clone can be used to bait Seraphine's E onto a fake target, wasting her primary CC.
Do not use R unless Seraphine's E is on cooldown, as she will interrupt your channel.

You should roam at level 6 using your W disguise to approach mid lane undetected — Jinx and Zeri can handle a 1v1 short trade window, and a successful mid roam with R can snowball the game.
Avoid roaming when the wave is pushing toward your tower, as Jinx will freeze it and deny Zeri CS while you're gone.

Do not use your E reactively to peel for Zeri — your E is your primary kill setup tool and using it defensively wastes its offensive value; Zeri's mobility is her own peel.
Overcommitting to trades when Seraphine has her full combo available will get you killed, as her R+E chain counters your R channel directly.

Created on 06/25/2026

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