Who Wins
- You lose level 2 fights due to Karma's superior early damage and shield utility combined with Kai'Sa's burst potential.
- At level 6, the matchup becomes more even as your R provides strong disengage and setup potential, though their all-in is still dangerous.
Synergy & Trading
- Use E on Mel during her Q poke to maximize damage and slow application, then look for Q bubbles on slowed targets or enemies caught by Mel's E root.
- Your W bounces work well with Mel's consistent damage output to maintain health advantages.
Wave Control/Roaming
- Roam when Mel has pushed the wave with Q and enemies are low on resources, typically after successful poke sequences.
- Look for mid lane roams around level 4-5 when your Q and E provide strong gank setup potential.
Mistakes to Avoid
- Don't use Q predictively against Karma since her E movement speed makes dodging easy, wait for Mel's E root or other CC first.
- Avoid staying in range of Kai'Sa's W evolution poke without proper positioning behind minions.
Created on 11/30/2025
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