Who Wins
- You win levels 1-2 through sustain advantage and Q disengage potential, negating Nautilus all-in while Kai'Sa outranges Samira.
- You hard lose post-level 3 if Nautilus lands Q on either of you, as Samira's burst combined with his CC chain exceeds your healing and disengage - your Q cannot stop their lethal damage once engaged.
Synergy & Trading
- Avoid trading aggressively as Samira + Nautilus hard win all-ins post-3 - focus on sustaining Kai'Sa with W bounces and saving Q for Nautilus engage interrupts.
- Use E on Kai'Sa only for brief poke windows when Nautilus abilities are on cooldown, then immediately back off to maximum range to deny engage angles.
Wave Control/Roaming
- Never roam in this matchup as Kai'Sa requires your sustain and Q disengage to survive Nautilus + Samira all-ins and to maintain safe farming distance.
- Your presence is critical for preventing engages and keeping Kai'Sa healthy - one missed Q interrupt or absence results in guaranteed kills for the enemy.
Mistakes to Avoid
- Never waste Q on poke or minions when Nautilus has Q available - save it exclusively to interrupt his engage, as one missed Q interrupt guarantees death for you or Kai'Sa.
- Avoid positioning where Samira can E onto you or where Nautilus can Q through minions, as you're the primary target - if you die first, Kai'Sa has no disengage and dies immediately after.
Enhanced by Anonymous
on 11/30/2025