Lulu & Twitch vs Vayne & Senna
Bot Lane MatchupLulu vs Vayne (with Twitch & Senna) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
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VS
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Who Wins
- You lose pre-6 due to Senna's superior range and poke damage overwhelming your shield and sustain.
- Post-6 you can win if you successfully polymorph Vayne during Twitch's R engage window.
Synergy & Trading
- Lead trades with Q poke, then W Twitch for attack speed when he commits to auto-trading.
- Save E shield for when enemies retaliate rather than using it proactively for poke.
Wave Control/Roaming
- Roam when Twitch has Q available for safety and the wave is pushing away from you.
- Best timings are after successful recalls or when your jungler is invading bot side jungle.
Mistakes to Avoid
- Don't waste W polymorph on Senna since she can just walk away and continue poking.
- Always save it for Vayne's all-in attempts or when Twitch needs protection during his stealth cooldown.
Created on 06/04/2026
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