Who Wins
- You lose pre-6 as Miss Fortune out-ranges your engage tools and Zoe's E makes your telegraphed E easy to punish with sleep.
- Post-6 the matchup remains difficult as Miss Fortune's R forces you to disengage while Zoe's R + E combo creates picks from unexpected angles.
Synergy & Trading
- Look for E engages when Miss Fortune steps up to Q bounce or when Zoe moves forward to Q poke, immediately following with Q and W for maximum burst.
- Only engage when Zoe's E is on cooldown or when you can guarantee the kill before sleep lands.
Wave Control/Roaming
- Roam after shoving waves when Miss Fortune recalls or when your ADC can safely farm under tower.
- Best roam timings are level 3-4 when your E-Q combo is strongest and mid/jungle skirmishes are frequent.
Mistakes to Avoid
- Don't engage when Zoe has E available as sleep will cancel your combo and leave you exposed to Miss Fortune's full damage rotation.
- Avoid using E through minions as Miss Fortune can easily sidestep and punish with Q bounce damage.
Created on 03/23/2026
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