Caitlyn & Thresh vs Vayne & Nautilus
Bot Lane MatchupCaitlyn vs Vayne (with Thresh & Nautilus) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
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VS
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Who Wins
- You dominate pre-6 with 650 range versus Vayne's 550, allowing free poke and CS denial.
- Post-6 becomes riskier as Nautilus R guarantees Vayne can reach you despite your range advantage.
Synergy & Trading
- Auto-attack Vayne whenever she steps up for CS, then use Q through minions to extend trades.
- Place W traps behind Vayne when Thresh lands Q to guarantee follow-up damage.
Wave Control/Roaming
- Maintain slow push to build minion advantage for trades, then crash waves to recall safely.
- Avoid hard shoving unless you have deep vision as Vayne scales better and benefits from farming under tower.
Mistakes to Avoid
- Never use E aggressively for damage as it's your only escape tool against Nautilus engage.
- Avoid overextending for poke when Nautilus has R available as his ultimate range matches your auto-attack range.
Created on 06/14/2026
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