Caitlyn & Seraphine vs Zeri & Senna
Bot Lane MatchupCaitlyn vs Zeri (with Seraphine & Senna) BOT matchup tips: who wins, how to trade, wave control and common mistakes.
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Who Wins
- You win pre-6 trades due to superior range and Seraphine's poke, but Zeri's mobility makes extended trades difficult.
- Post-6 you maintain advantage through range control, though Zeri's R can create dangerous all-in windows if she gets close.
Synergy & Trading
- Use Q through minions to poke both enemies while Seraphine lands Q, then auto-attack the closer target.
- Follow up with W-E combo if they engage, using your range to kite back while Seraphine provides follow-up damage.
Wave Control/Roaming
- Push early waves to establish range advantage and deny Zeri's ability to charge passive off minions.
- Maintain slow pushes to keep minions between you and Zeri, making her Q less effective while enabling your Q poke.
Mistakes to Avoid
- Don't waste E defensively against Zeri's poke - save it for when she commits with W or R.
- Avoid fighting in open areas where Zeri can freely kite with her mobility.
Created on 06/06/2026
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