Ashe & Senna vs Caitlyn & Seraphine

Ashe
You
Senna
VS

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Who Wins

  • Pre-6: Caitlyn-Seraphine wins due to superior range and poke damage, with your 600 range being outmatched by Caitlyn's 650 and her Q harass.
  • Post-6: The matchup becomes more even as your R provides strong engage potential, but they still maintain trading advantages.

Synergy & Trading

  • Focus on W poke when Caitlyn uses Q on minions, then follow up with auto-attacks while Senna provides Q heal sustain.
  • Avoid extended trades unless Senna lands W root, as Caitlyn's headshot passive and range advantage will win most sustained exchanges.

Wave Control/Roaming

  • Push for early level 2 advantage with Senna's soul collection, then look to freeze near your tower to force Caitlyn into W range.
  • Avoid slow pushing as Caitlyn excels at punishing under tower with her range advantage.

Mistakes to Avoid

  • Don't use W aggressively without vision as Seraphine's E can easily punish your immobility during the cast animation.
  • Never engage with R unless Senna has W ready, as you lack the damage to follow through alone against their sustain and disengage.
Created on 01/07/2026
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